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<![CDATA[Metabolic Syndrome In Psoriasis Vulgaris Patient ]]>
<![CDATA[Wulan Yuwita]]>;
<![CDATA[Hendra Gunawan]]>;
<![CDATA[Unwati Sugiri]]>;
<![CDATA[Dendi Sandiono]]>
<![CDATA[ Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Airlangga ]]>
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DOI: 10.20473/bikk.V28.3.2016.251-255
<![CDATA[Background: The management of metabolic syndrome in psoriasis vulgaris is rather complicated, including lifestyle modification, diet intake intervention, increasing daily activities, and managing the comorbidity factors. Purpose: Management of metabolic syndrome in psoriasis vulgaris requires holistic approach. Case: A case of metabolic syndrome with psoriasis vulgaris in a-56-year-old woman was reported with chief complaint generalized erythematous plaques, papules, scales, and hyperpigmented macules. Blood pressure was 160/90 mmHg with central obesity and waist circumference was 98 centimeters. The patient manifested with onychodystrophy and subungual hyperkeratosis digiti I pedis bilateral. Fasting blood glucose was 119 mg/dL, and triglyceride was 185 mg/dL. Management: Patient management included methotrexate, bisoprolol, captopril, simvastatin, lifestyle modification, and diabetic diet (1300 kkal and protein 0.8 mg/kg/body weight/day). Conclusion: Holistic management revealed a good response in this case. The initial psoriasis area and severity index (PASI) score before therapy was 24.8, became 9.0 after therapy on day 155th of observation.]]>
<![CDATA[Topical Therapy in Atopic Dermatitis Patient ]]>
<![CDATA[Wahyunita Desi Ratnaningtyas]]>;
<![CDATA[Marsudi Hutomo]]>
<![CDATA[ Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Airlangga ]]>
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DOI: 10.20473/bikk.V28.3.2016.210-216
<![CDATA[Background: Atopic dermatitis (AD) is an inflammation skin disorder characterized by itchy, chronic, residif, can occur in infant, child, and adult. The therapy for AD are divided into systemic and topical therapy. Topical therapy is the first line therapy for mild and moderate AD which are the most common type AD. Purpose: To evaluate the pattern of topical therapy in new AD patients. Methods: Retrospective study methods was performed by evaluating medical records of new AD patients who received topical therapy in Allergy Immunology Division, Department of Dermatology and Venereology, Dr. Soetomo General Hospital from 2013 until 2015. The evaluated data included the patient's visitation, age, gender, time visit, patient's complaint, periode of illness, history of atopy, physical examination, management, and follow up. Results: There were 272 patients (83.2%) of 327 new AD patients who received topical therapy. Topical therapies were provided in form of corticosteroid topical for 187 patients (23.6%), emolient for 183 patients (23.1%), and topical antibiotic for 40 patients (5.1%). Patients who did not return to the hospital after first visitation were 174 patients (53.2%). Conclusion: Corticosteroid topical is the first line therapy for atopic dermatitis, but emolient is important to improve skin barrier.]]>
<![CDATA[The Effects of Platelet Rich Plasma Topical Gel on Chronic Plantar Ulcer Healing in Leprosy Patient ]]>
<![CDATA[Diana Kartika Sari]]>;
<![CDATA[M. Yulianto Listiawan]]>;
<![CDATA[Diah Mira Indramaya]]>
<![CDATA[ Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Airlangga ]]>
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DOI: 10.20473/bikk.V28.3.2016.175-181
<![CDATA[Background: Plantar ulcer is a physical disability that most often occurs in approximately 10-20% of leprosy patient. Conventional therapies such as dressings, surgical debridement, and skin graft can not provide satisfactory improvement. Platelet rich plasma (PRP) has a variety of growth factors required in ulcer wound healing. Purpose: To prove the effect of PRP topical gel to the size of wound, macrophage activation, neovascularization, fibrosis, and formation of granulation tissue on chronic plantar ulcer healing in leprosy patients. Methods: The analytic cohort study of 20 leprosy patients with chronic plantar ulcer in Morbus Hansen Division, Dermatology and Venereology Outpatient Clinic, Dr. Soetomo Hospital Surabaya. Biopsies were performed before and after PRP topical gel treatment on leprosy patient with chronic plantar ulcers. Results: After two doses of PRP topical gel, wound size of 9 patients (45%) was reduced <0.5 cm. Statistycal analysis showed significant differences in size of lesions (p = <0.05), the number of macrophages (p = <0.001), number of capillaries (p = 0.003), and the amount of granulation (p = 0.032) before and after PRP topical gel treatment. While the results of the analysis of the number of fibroblasts showed no significant difference (p = <0.05). Conclusion: PRP topical gel treatment gives good results, in terms of improvement in wound size, an increase in macrophages, neovascularization and granulation tissue.]]>
<![CDATA[Penile Ulcer Caused by Lintah Oil Injection ]]>
<![CDATA[Kartika Paramita]]>;
<![CDATA[Cita Rosita Sigit Prakoeswa]]>
<![CDATA[ Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Airlangga ]]>
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DOI: 10.20473/bikk.V28.3.2016.256-259
<![CDATA[Background: Lintah oil that was injected for genital augmentation, can cause penile ulcer, which is also one of the ulcer that occur due to ‘self-inflicted’. It could occur in nodul or abscessformation, and undergoes ulceration. It can cause psychological stress to affected patient, so that a proper diagnosis is expected to support well management. Purpose: To describe the clinical manifestation, laboratory examination, and management of penile ulcer caused by lintah oil injection. Case: A 58-year-old male presented a single deep wound on his shaft penis, with diameter ± 2 x 5 cm, undermined, ragged edges, containing pus and easily to bleed, occured about 6 months after the injection of lintah oil, which was used for his genitalia enlargement and performed by untrained person. There were complaints about redness skin and swelling on his shaft penis about 3 months after the injection, which then underwent fester with the sense of burning sensation and painful. Discussion: Blood examination indicated a slightly increase of leukocyte. Pus culture and sensitivity test were performed, while waiting for the result, patient was given cotrimoxazole tablet 480 mg twice daily for seven days. Another examination result were within normal limit. Treatment consisted of oral antibiotic for seven days, and for the wound dressing has given NaCl 0.9% as the wet dressing and covered with framycetin sulfate 1% gauze. Conclusion: Diagnosis of penile ulcer caused by lintah oil injection was established by patient’s history and physical examination. Therapy was given based on culture result. Lesion was healed after 1 month of treatment. Education not to repeat the injection was given to the patient to prevent the recurrence of this condition.]]>
<![CDATA[Profile of Condylomata Acuminata in Patients with HIV/AIDS ]]>
<![CDATA[Dian Pertiwi Habibie]]>;
<![CDATA[Jusuf Barakbah]]>
<![CDATA[ Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Airlangga ]]>
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DOI: 10.20473/bikk.V28.3.2016.217-222
<![CDATA[Background: Condylomata acuminata is human papilloma virus (HPV) infection, and one of the most common sexually transmitted disease, characterized with papul or papillomatous nodul in genital, perineum and anal, this disease can be asymptomatic as well. Some study proved sexually transmitted infection increase the incidence of Human immunodeficiency virus (HIV)/ acquired immunodeficiency syndrome (AIDS), and vice versa. Purpose: To evaluate the profile of condylomata acuminata in HIV/AIDS patients. Methods: Retrospective study of the incident of condylomata acuminata in HIV/AIDS patients using medical record within 4 years period from 2011 to 2014. Results: HIV/AIDS patients in outpatient clinic intermediate care infection disease unit RSUD Dr.Soetomo Surabaya in period 2011-2014 is 4057 patients, 63 (1.15%) of it with condylomata acuminata. HIV/AIDS patients with condylomata acuminata at the age group 25-44 (69.8%), the most sexual partner is heterosexual (58.7%), CD4+ count group mostly shown < 200/mm3 (46.0%), most of the patients got antiretroviral therapy (ART) as 66.7%, the most therapy for condylomata acuminata is trichloracetic acid (TCA) with fucidic acid (98.4%), most of the patient through 1-3 times therapy (50.8%), and the result is mostly not yet healed (76.2%). Conclusion: Most of condylomata acuminata patient in outpatient clinic intermediate care infection disease unit (UPIPI) got ART, TCA, and fucidic acid, and not complete resolution.]]>
<![CDATA[Melanocyte Function and Count of Leukotrichia in Vitiligo Using S100 Immunohistochemistry and Microphtalmia Associated Transcription Factor (MITF) ]]>
<![CDATA[M. Yulianto Listiawan]]>;
<![CDATA[Marina Rimadhani]]>;
<![CDATA[Willy Sandhika]]>
<![CDATA[ Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Airlangga ]]>
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DOI: 10.20473/bikk.V28.3.2016.182-185
<![CDATA[Background: Melanocyte of the hair follicle is one of the major sources of repigmentation in vitiligo. Leukotrichia is complete depigmentation with significant bleaching hair. Leukotrichia in nonsegmental vitiligo may contribute to the lack of response to medical treatment. Leukotrichia is often associated with absent of melanocyte, showing poor prognosis for vitiligo treatment. Purpose: To evaluate melanocyte count and function of leukotrichia’s melanocyte in vitiligo and comparing with other feature. Method: Melanocyte count in each feature of lesional skin in 18 segmental vitiligo patients were evaluated based on vitiligo extent tensity index (VETI). Melanocyte count has been evaluated using immunohistochemistry S100 and microphtalmia associated transcription factor (MITF). Results: Eighteen patients were nonsegmental vitiligo, and five of them had leukotrichia. Two of five leukotrichia patients did not express MITF nor melanocyte. There were no differences of melanocyte and MITF expression between patient with or without leukotrichia. Conclusion: Leukotrichia is a poor indicator for treatment response in vitiligo, but this research showed that leucotrichia may not contribute to the lack of response upon medical treatment.]]>
<![CDATA[Profile of Superficial Mycoses in Pediatric Dermatology Patient ]]>
<![CDATA[Maria Ulfa Sheilaadji]]>;
<![CDATA[Iskandar Zulkarnain]]>
<![CDATA[ Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Airlangga ]]>
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DOI: 10.20473/bikk.V28.3.2016.223-234
<![CDATA[Background: Superficial mycoses in children is a fungal infection of the skin, hair and nails that affected children aged 14 years and below. The superficial mycoses common in children are tinea capitis, pityriasis versicolor and diaper candidiasis. Purpose: To evaluate the distribution of superficial mycoses in pediatric patients in Pediatric Dermatology Division of Dermatology and Venereology Outpatient Clinic in Dr. Soetomo General Hospital Surabaya. Methods: Retrospective study using new patient’s medical record during the period of January 1 2013 until December 31 2015. Results: In period year 2013-2015 the total new superficial mycoses’s pediatric patients is 320 with the precentage in 2013 is 0.4%, in 2014 is 0.5%, and in 2015 is 0.4%. The proportion in male is more than female, and most frequent at aged 5-14 that 54.6%. Most common complain is itchy with the most common diagnosed is pitiriasis versicolor 28.3%. Potasium hydroxide is the most common additional examination in 70.3% and frequent use therapies are ketoconazole and griseofulvin orally. Conclusion: Superficial mycoses especially pitiriasis versicolor in pediatric is still a common issues in Indonesia, specially in Surabaya.]]>
<![CDATA[Increasing of Urinary 8-Hydroxydeoxyguanosine (8-OHdG) Levels in Children with Atopic Dermatitis ]]>
<![CDATA[Shakti Indraprasta]]>;
<![CDATA[Iskandar Zulkarnain]]>;
<![CDATA[Evy Ervianti]]>
<![CDATA[ Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Airlangga ]]>
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DOI: 10.20473/bikk.V28.3.2016.186-193
<![CDATA[Background: Atopic dermatitis (AD) is a chronic inflammation of the skin occurring in individuals with allergic diathesis. Reactive oxygen species (ROS) is assumed to be involved in the pathogenesis of allergic inflammation. 8-Hydroxydeoxyguanosine (8-OHdG) is a marker of oxidative DNA base damage. Previous research showed a various result in urinary 8-OHdG levels of AD in children. Purpose: To evaluate urinary 8-OHdG level of children with AD in Dermatology and Venereology Outpatient Clinic at Dr. Soetomo general hospital Surabaya. Methods: This is a descriptive observational cross sectional research in children with AD at Dermatology and Venereology Outpatient Clinic Dr. Soetomo hospital who qualified inclusion and exclusion criteria in three months period (March to June 2016). Urine sampling for 8-OhdG examination were underwent from all subjets. Results: Mean urinary 8-OHdG level of children with AD was 17.236 ± 13.596 ng/mL. Mean urinary 8-OHdG level of AD in children with mild, moderate, and severe based on grade of severity were 7.892 ± 5.596 ng/mL, 16.006 ± 13.662 ng/mL, and 27.321 ± 12.668 ng/mL respectively. Conclusion: There is a tendency of increased levels of urinary 8-OHdG in accordance with increasing grade of severity in children with AD which possibly caused by the role of oxidative stress in the pathogenesis of AD. Further research is needed to reveal the role of antioxidant in AD and the connection between the severity of AD and urinary 8-OHdG levels.]]>
<![CDATA[Bacterial Vaginosis ]]>
<![CDATA[Abdul Karim]]>;
<![CDATA[Jusuf Barakbah]]>
<![CDATA[ Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Airlangga ]]>
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DOI: 10.20473/bikk.V28.3.2016.235-242
<![CDATA[Background: Bacterial vaginosis (BV) is the most common cause of vaginal discharge symptoms in reproductive women. BV is the most common cause of malodor of vaginal discharge and fluor albus, but 50% of BV patients give no symptoms. Purpose: To evaluate the general overview and management of new BV patients at the Sexual Transmitted Infection Division of Dermatology and Venereology Outpatient Clinic Dr. Soetomo General Hospital Surabaya from the period of 2012-2014. Methods: A retrospective study was perfomed by evaluating medical records of new BV patients including basic data, history taking, examination, diagnosis, treatment, follow up, and counseling. Results: The overall number of new cases is 33. The majority age range 25-44 years old (57.6%) and 84.8% are married. The most main complaint is vaginal discharge without subjective complaints (42.4%), the most common type of complaint is recurrent ( 54.5%), the most sexual partners is husband (60.6%), usage history of vaginal douching (30.3%), the most vaginal discharge appearance is serous (75.8%), Whiff test positive and pH > 4.5 only 9.1% respectively. All microscopic preparation showed clue cell (100%). Therapy with metronidazole is given in 81.8%. Conclusion: The general overview of BV cases showed a small incidence with sexually active age group being the majority of cases and with the main complaint is vaginal discharge without other subjective complaint. The right management is needed to improve good service and reduce the recurrence rate.]]>
<![CDATA[Increase of Serum Zinc Levels in Patients with Vitiligo ]]>
<![CDATA[Dinar Witasari]]>;
<![CDATA[Hari Sukanto]]>;
<![CDATA[Trisniartami Setyaningrum]]>
<![CDATA[ Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Airlangga ]]>
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DOI: 10.20473/bikk.V28.3.2016.194-201
<![CDATA[Background: Vitiligo is a common acquired depigmentary disease characterized by depigmented patches of the skin, hair, and mucous membranes due to selective destruction of melanocytes. Zinc is one of the trace element that suspected to play an important role in pathogenesis of vitiligo. Previous research showed a controversial result in zinc level of vitiligo. Purpose: To compare serum zinc between vitiligo and control in Dermatology and Venereology Outpatient Clinic in Dr. Soetomo General Hospital Surabaya. Methods: Analitic observational case control research was conducted, with 19 vitiligo patients in Dermatology and Venereology Outpatient Clinic Dr. Soetomo hospital and 19 age-sex matched controls (non-vitiligo subjects) that were qualified with inclusion and exclusion criteria. Serum zinc level was measured in both groups using atomic absorbtion spectrophotometer. Results: Mean serum zinc in vitiligo groups were 254.53 µg/dL and 109.53 µg/dL in control groups. This results showed that mean serum zinc in vitiligo group significantly higher compared to control group (p<0,05). There was a statistically significant association between serum zinc level and progressivity of the lesion as patient with active vitiligo lesion showed higher values of serum zinc. Stress is the most common predisposing factors (36%), meanwhile stress can also induce the increasing of serum zinc. Conclusion: Serum zinc in vitiligo patient is higher than control and showed correlation with course of the disease. It is required further research to reveal the role of zink in vitiligo and the connection between the degree of stress and serum zinc.]]>
